Table 2 Prognostic value of high vs. low levels of IL- 6, TNF-α and CRP for mortality
All-cause mortality | Events | Adjusted | ||
|---|---|---|---|---|
Low plasma levels | High plasma levels | HR* (95% CI) | p-value | |
30-day all-cause mortality | ||||
IL- 6 | 16/552 (2.9%) | 43/444 (9.7%) | 3.50 (1.95 to 6.28) | < 0.001 |
TNF-α | 25/485 (5.2%) | 34/511 (6.7%) | 1.33 (0.79 to 2.23) | 0.288 |
CRP | 37/723 (5.1%) | 17/234 (7.3%) | 1.60 (0.84 to 3.04) | 0.153 |
180-day all-cause mortality | ||||
IL- 6 | 83/552 (15.0%) | 115/444 (25.9%) | 1.97 (1.47 to 2.63) | < 0.001 |
TNF-α | 93/485 (19.2%) | 105/511 (20.5%) | 1.08 (0.82 to 1.44) | 0.58 |
CRP | 140/723 (19.4%) | 45/234 (19.2%) | 1.22 (0.84 to 1.77) | 0.298 |
1-year all-cause mortality | ||||
IL- 6 | 131/500 (26.2%) | 157/411 (38.2%) | 1.75 (1.38 to 2.23) | < 0.001 |
TNF-α | 134/436 (30.7%) | 154/475 (32.4%) | 1.10 (0.87 to 1.39) | 0.428 |
CRP | 207/665 (31.1%) | 64/211 (30.3%) | 1.25 (0.91 to 1.71) | 0.166 |
2-year all-cause mortality | ||||
IL- 6 | 186/500 (37.2%) | 207/411 (50.4%) | 1.68 (1.37 to 2.06) | < 0.001 |
TNF-α | 187/436 (42.9%) | 206/475 (43.4%) | 1.06 (0.87 to 1.29) | 0.578 |
CRP | 288/665 (43.3%) | 86/211 (40.8%) | 1.09 (0.83 to 1.43) | 0.529 |
3-year all-cause mortality | ||||
IL- 6 | 206/552 (37.3%) | 221/444 (49.8%) | 1.66 (1.37 to 2.02) | < 0.001 |
TNF-α | 206/485 (42.5%) | 221/511 (43.2%) | 1.05 (0.87 to 1.27) | 0.612 |
CRP | 313/723 (43.3%) | 93/234 (39.7%) | 1.08 (0.84 to 1.41) | 0.542 |
5-year all-cause mortality | ||||
IL- 6 | 217/500 (43.4%) | 227/411 (55.2%) | 1.60 (1.32 to 1.94) | < 0.001 |
TNF-α | 213/436 (48.9%) | 231/475 (48.6%) | 1.03 (0.86 to 1.25) | 0.73 |
CRP | 327/665 (49.2%) | 95/211 (45.0%) | 1.07 (0.82 to 1.38) | 0.624 |