Fig. 5

Relative mRNA expression level of Inflammation and cell death associated genes of P301S mice show distinct pattern compared to their age matching wild type controls. The relative mRNA expression levels are presented by bar graphs for (a) NFE2L2 showing an increased expression level at 2 month age of P301S compared to WT that is followed with reduction at 4 and 6 months age (b) HMOX1 expression is significantly reduced compared to WT at 6 months (c) Iba1, (d)IL-1β showed a high expression at 6 month, (e) IL-6, (f) IL-17 A (g) IL-10 showed a significant reduction at 2 and 6 months groups, (h) iNOS, (i)TNF-α, (j) Bax, (k) Bcl-2 and (l) Caspase 3. Data are shown as mean +/- SEM of 4–6 mice per group, and significance is tested with One-way ANOVA test followed with post hoc Tukey test when significance between tested groups were detected. * p < 0.05, ** p < 0.01. x-axis shows the relative mRNA expression in all graphs