Fig. 1

A progressive memory deficit of P301S in hippocampal dependent tasks using Morris Water Maze a, b, c: Dot chart demonstrating the latency time to reach platform (in seconds) in MWM from Day 1 to Day 3 showing a significant defect in the performance of P301S mice compared to the two, four and six months age matching WT mice. d. Bar chart demonstrates the mean of time spent in the target quadrant (TQ) during the probe trial of MWM, showing an age dependent significant impairment of retrieving the correct site of the platform for P301S mice in addition to the significant reduction in comparison to WT strains at 6 month-age. e. Representative tracking chart of ANYMAZE for 6 month-age WT and P301S mice showing the lack of preference to swim at the target quadrant (TQ) for P301S in comparison to WT mice. f. Bar graph representing the average swimming speed (m/sec) in MWM arena during the probe test day, showing a significant increase of the speed for 2 months P301S compared to the age matching WT and other groups. g. Bar graph representing the mean of total distance (m) covered by each group during the probe test in MWM arena, showing the significant hyperkinesia of 2 M P301S compared to other groups. Data are shown as mean ± SEM of 9–11 mice per group, and significance is tested with Students T test when comparing between P301S and WT strains of the same age, or using one way ANOVA test with post-hoc Tukey HSD test when comparing P301S at different age points or Kuskal-Wails followed with Dunn’s multiple comparison test. * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001