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Fig. 4 | Journal of Inflammation

Fig. 4

From: Emodin alleviates intestinal ischemia–reperfusion injury through antioxidant stress, anti-inflammatory responses and anti-apoptosis effects via Akt-mediated HO-1 upregulation

Fig. 4

A Pro-inflammatory cytokines, including TNF, IL-6, IL-1β, and CXCL1, were decreased following the administration of Emodin. B Different doses of Emodin attenuated OGD/R-associated apoptosis. C Different doses of Emodin inhibited OGD/R-induced apoptosis by downregulating pro-apoptosis-associated proteins such as cleaved Caspase-3/Caspase-3 and Bax, while upregulating anti-apoptosis-associated proteins like Bcl-2. Proteins that regulate apoptosis, such as p-Akt/Akt and HO-1, were also altered accordingly. Quantitative analysis of the expression compared with β-actin was shown beside

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Journal of Inflammation

ISSN: 1476-9255

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